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Promethazine HCl Oral Remedy is contraindicated in comatose states, and in men and women known to get hypersensitive or to have experienced an idiosyncratic response to promethazine or to other phenothiazines.
Will not consider any benzodiazepines or medicines that could potentially cause drowsiness or sleepiness during treatment method with Promethazine Hydrochloride and Codeine Phosphate Oral Answer. Check with your Health care company for a summary of these medicines if you are not confident.
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The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers less than 6 yrs of age. Concomitant administration of promethazine solutions with other respiratory depressants has an Affiliation with respiratory melancholy, and sometimes Demise, in pediatric individuals.
Enhanced tension in your head (amplified intracranial pressure). Keep away from the usage of Promethazine Hydrochloride and Codeine Phosphate Oral Solution Should you have a head injury or are actually advised you have alterations while in the tissue of one's brain (Mind lesions) or increased strain inside your head.
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Promethazine HCl and Codeine Phosphate Oral Answer is indicated for the non permanent relief of coughs and higher respiratory indications affiliated with allergy or maybe the prevalent chilly in people eighteen years of age and more mature.
Promethazine HCl Oral Option might decrease seizure threshold. It should be applied with caution in individuals with seizure Issues or in persons who will be working with concomitant drugs, including narcotics or local anesthetics, which can also influence seizure threshold.
Abuse and dependancy are different and distinctive from Actual physical dependence and tolerance. Well being care companies must be knowledgeable that habit will not be accompanied by concurrent tolerance and signs and symptoms of Bodily dependence in all addicts. Moreover, abuse of opioids can occur while in the absence of legitimate dependancy.
Critical respiration complications. Promethazine HCl Oral Solution should not be used in individuals with weak lung function such as chronic obstructive lung condition or respiratory problems whilst sleeping (slumber apnea.)
The opioid antagonists, naloxone and nalmefene, are unique antidotes for respiratory despair resulting from opioid overdose. For clinically considerable respiratory or circulatory depression secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered from the absence of clinically important respiratory depression. As the length of opioid reversal is expected to generally be under the duration of motion of codeine in Promethazine HCl and Codeine Phosphate Oral Remedy, cautiously monitor the client right up until spontaneous respiration is reliably reestablished.
Since opioid agonists might improve biliary tract tension, with resultant rise in plasma amylase or lipase amounts, determination of those enzyme amounts might be unreliable for twenty-four hours after administration of the dose of Promethazine HCl and Codeine Phosphate Oral Answer.
Promethazine is effectively absorbed from the gastrointestinal tract. Clinical consequences are obvious within just twenty minutes right after oral administration and usually last 4 to 6 hrs, While they may persist given that twelve several hours.